RT Journal Article SR Electronic A1 Vinall, Phil T1 Dramatic Early Improvement in the NINDS Trial: Better 90 Day Outcomes and No Increased Rates of Intracranial Hemorrhage JF MD Conference Express YR 2009 FD SAGE Publications VO 9 IS 1 SP 17 OP 18 DO 10.1177/155989770901009 UL http://mdc.sagepub.com/content/9/1/17.abstract AB This article discusses the results of a retrospective study that used data from the rt-PA arm of the National Institute of Neurological Disorders (NINDS) trial [Kwiatkowski TG et al. N Engl J Med 1999] to evaluate dramatic early improvement after treatment with IV-rt-PA as a risk factor for the development of posttreatment ICH. A secondary objective was to characterize the subgroup of patients with dramatic early improvement.