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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents an overview of the prevalence, risk factors, mechanisms, treatments, and related clinical trials for smoking addiction.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ESmoking Cessation\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ESubstance-Related Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPrevention \u0026amp; Screening\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EPrevalence of Cigarette Smoking\u003C\/h2\u003E\n         \u003Cp id=\u0022p-2\u0022\u003ERobert A. Kloner, MD, University of Southern California, Los Angeles, CA, presented an overview of the prevalence, risk factors, mechanisms, and treatments for smoking addiction during a special session at the American College of Cardiology Scientific Session in Orlando, Florida.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EThe World Health Organization estimates that there are 1.3 billion tobacco smokers globally, of which 47% are men and 12% are women [WHO Bulleitin 2004]. In Latin America and the Caribbean the Disease Control Priorities Project reports a rate of 40% for men and 24% for women [Disease Control Priorities in Developing Countries. Second edition. 2006, Table 46.1]. Although more than 70% of smokers want to quit and 30% to 50% attempt to quit each year, only 3% to 5% who succeed without some form of assistance remain cigarette free after 12 months [Hughes JR et al. \u003Cem\u003EAddiction\u003C\/em\u003E 2004].\u003Csup\u003E3\u003C\/sup\u003E\n         \u003C\/p\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-2\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003ESmoking as a Risk Factor Across an Array of Diseases\u003C\/h2\u003E\n         \u003Cp id=\u0022p-4\u0022\u003ETobacco use kills 5.4 million people a year-an average of one person every six seconds-and accounts for one in 10 adult deaths worldwide [\u003Ca href=\u0022http:\/\/www.who.int\/topics\/tobacco\/facts.en\u0022\u003Ehttp:\/\/www.who.int\/topics\/tobacco\/facts.en\u003C\/a\u003E]. It is the single largest cause of preventable death. The annual cost of health care directly related to smoking addiction is estimated at $96 billion [Mokdad AH et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2004]. The negative effects of smoking on the body are broad and varied. Smoking affects the cardiovascular, respiratory, and reproductive systems and is a leading cause of cancer in a number of different organs. In the cardiovascular system, smoking induces coronary artery disease (CAD) by reducing nitric oxide biosynthesis and increasing oxidative stress, white blood cell counts, thrombogenicity, and endothelial dysfunction. In addition, smoking is associated with a risk of angina, acute myocardial infarction (MI), sudden cardiac death, and Q-wave MI after percutaneous coronary revascularization. The risk of fatal CAD is directly correlated with the number of cigarettes consumed per day. Individuals smoking \u0026gt;25 cigarettes\/day have a 5.4 greater risk of a fatal CAD event compared to nonsmokers (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E)[Willett WC et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 1987]. Besides CAD, smoking is the cause of 12% to 14% of all stroke deaths [Goldstein LB et al. \u003Cem\u003EStroke\u003C\/em\u003E 2006].\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Increased CAD Mortality.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1493281784\u0022 data-figure-caption=\u0022Increased CAD Mortality.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11552\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EIncreased CAD Mortality.\u003C\/p\u003E\n            \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003ECopyright \u00a9 Massachusetts Medical Society 1987. All rights reserved.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-3\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EBenefits of Smoking Cessation\u003C\/h2\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EThe benefits of ceasing to smoke are almost immediate, with cosmetic benefits noted within weeks and improved lung function seen after 3 months. After 1 year, the excess CAD risk attributable to smoking is reduced by 50% in ex-smokers, and after 15 years it is similar to that of individuals who had never smoked [CDC. \u003Cem\u003EMMWR\u003C\/em\u003E 1990]. The OR for the risk of acute MI drops significantly from 2.95 (95% CI, 2.77 to 3.14) to 1.22 (95% CI, 1.09 to 1.37; p\u0026lt;0.0001) after 20 years of smoking cessation [Teo KK et al. \u003Cem\u003ELancet\u003C\/em\u003E 2006]. A similarly significant (p\u0026lt;0.0001) trend for a reduced risk of stroke is seen in ex-smokers (\u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003EFigure 2\u003C\/a\u003E)[Robbins AS et al. \u003Cem\u003EAnn Intern Med\u003C\/em\u003E 1994].\u003C\/p\u003E\n         \u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Reduced Risk of Stroke.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1493281784\u0022 data-figure-caption=\u0022Reduced Risk of Stroke.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 2.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F2.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11555\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2.\u003C\/span\u003E \n               \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EReduced Risk of Stroke.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-4\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003ENature of Nicotine Addiction\u003C\/h2\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThe addictive characteristics of nicotine are a result of its rapid uptake and the subsequent intense release of dopamine in the brain. In addition, the \u03b14\u03b22 nicotinic acetylcholine receptors have a significant role in mediating the reinforcing and dependence-producing effects of nicotine [Coe JW et al. \u003Cem\u003EJ. Med. Chem\u003C\/em\u003E 2005]. Although smokers can self-regulate nicotine levels by selecting the frequency of cigarette consumption and choosing the intensity of inhalation [Schroeder SA. \u003Cem\u003EJAMA\u003C\/em\u003E 2005], nicotine is rapidly cleared from the central nervous system. Its short half life (2 hours) in combination with tolerance-inducing up-regulation and decreased sensitivity of receptors can result in withdrawal symptoms including depressed mood, irritability, increased appetite, concentration difficulties, insomnia, anxiety and decreased heart rate [Han ES et al. \u003Cem\u003EInt J Clin Pract\u003C\/em\u003E 2006]. Dr. Kloner said it was important to point out that tobacco dependence is a chronic medical condition and relapse is a component of this condition, not an indication of patient or clinician failure.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-5\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EPharmacotherapies as Aids to Smoking Cessation\u003C\/h2\u003E\n         \u003Cp id=\u0022p-9\u0022\u003EAs part of its Tobacco Free Initiative (TFI) the WHO recommends that treatment of tobacco dependence be addressed through a health systems approach that focuses on promoting and integrating clinical best practices (behavioral and pharmacological) which help tobacco-dependent consumers increase their chance of quitting successfully [\u003Ca href=\u0022http:\/\/www.who.int\/tobacco\/resources\/publications\/tobacco_dependence\/en\/index.html\u0022\u003Ehttp:\/\/www.who.int\/tobacco\/resources\/publications\/tobacco_dependence\/en\/index.html\u003C\/a\u003E]. The American Association of Family Practice developed the ASK (only 70% of physicians ask patients about their tobacco use) and ACT (only 40% of physicians act to help patients with tobacco use dependency problems) programs. There are a number of counseling, as well as pharmacotherapy options (varenicline, bupropion HCl, and nicotine replacement therapy) to help smokers increase long-term smoking abstinence rates.\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003ERobert M. Anthenelli, MD, University of Cincinnati College of Medicine, Cincinnati, OH, discussed the results from clinical trials of varenicline, the latest option for treating tobacco addiction. Varenicline functions as \u03b14\u03b22 nicotinic receptor partial agonist to inhibit dopaminergic activation produced by smoking, while simultaneously providing relief from the craving and the withdrawal syndrome that accompanies cessation attempts [COE JW et al. \u003Cem\u003EJ Med Chem\u003C\/em\u003E 2005]. This dual acting inhibitor blocks nicotine from binding to receptors and limits the release of dopamine, thus reducing the pleasure effect of nicotine and the reinforcing\/rewarding effect of dopamine release.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-6\u0022\u003E\n         \u003Ch2 class=\u0022\u0022\u003EClinical Trials\u003C\/h2\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EIn two randomized clinical trials, varenicline (1 mg twice daily) was shown to reduce craving and withdrawal effects and, for those who smoked while receiving the study drug, smoking satisfaction. For Weeks 9 through 12, the 4-week continuous abstinence rates were 44.0% for varenicline versus 17.7% for placebo (OR, 3.85; 95% CI, 2.70 to 5.50; p\u0026lt;0.001) and versus 29.5% for bupropion SR (OR, 1.93; 95% CI, 1.40 to 2.68; p\u0026lt;0.001) for both trials. For weeks 9 through 52, the continuous abstinence rates were 21% and 22% for varenicline versus 8.4% and 10.3% for placebo (p\u0026lt;0.001) and 16.1% (p=0.057) and 14.6% (p=0.004) for bupropion SR (\u003Ca id=\u0022xref-fig-3-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F3\u0022\u003EFigure 3\u003C\/a\u003E)[Gonzales D et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2006; Jorenby DE et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2006]. The most common adverse events (AEs; \u0026gt;10%) for participants receiving varenicline were nausea (30%), insomnia (18%), headache (15%), and abnormal dreams (13%).\u003C\/p\u003E\n         \u003Cdiv id=\u0022F3\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F3.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Varenicline Superior to Bupropion in 2 Head-to-Head Trials.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1493281784\u0022 data-figure-caption=\u0022Varenicline Superior to Bupropion in 2 Head-to-Head Trials.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 3.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F3.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F3.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 3.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F3.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11558\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 3.\u003C\/span\u003E \n               \u003Cp id=\u0022p-12\u0022 class=\u0022first-child\u0022\u003EVarenicline Superior to Bupropion in 2 Head-to-Head Trials.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-13\u0022\u003EIn another clinical trial to determine whether smokers who quit after 12 weeks of treatment with varenicline maintain higher abstinence rates than placebo-treated patients with an additional 12 weeks of treatment, abstinence rates for varenicline versus placebo subjects for Weeks 13 to 24 were 70.5% versus 49.6% (OR, 2.48; 95% CI, 1.95 to 3.16; p\u0026lt;0.001) and 43.6% versus 36.9% for weeks 13 to 52 (OR, 1.34; 95% CI, 1.06 to 1.69; p=0.02; \u003Ca id=\u0022xref-fig-4-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F4\u0022\u003EFigure 4\u003C\/a\u003E)[Tonstad S et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2006]. This data suggests that patients should receive additional treatment if they have early lapses after their target quit date.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F4\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F4.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Maintenance of Abstinence.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1493281784\u0022 data-figure-caption=\u0022Maintenance of Abstinence.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 4.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F4.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F4.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 4.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F4.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11561\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 4.\u003C\/span\u003E \n               \u003Cp id=\u0022p-14\u0022 class=\u0022first-child\u0022\u003EMaintenance of Abstinence.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-15\u0022\u003EIn patients with a history of MI, coronary revascularization, angina pectoris, peripheral arterial vascular disease, or cerebrovascular disease (CVD) diagnosed for \u0026gt;2 months, varenicline as a treatment for smoking cessation is efficacious and has an acceptable safety profile, according to a results of a study presented in a poster by Nancy A. Rigotti, MD, Massachusetts General Hospital and Harvard Medical School, Boston, MA.\u003C\/p\u003E\n         \u003Cp id=\u0022p-16\u0022\u003EIn this randomized, double-blind study, smokers (n=714) were randomly assigned to receive either varenicline (1.0 mg twice daily) or placebo for a 12 weeks. The target date for smoking cessation was 8 days after treatment initiation. Patients also received concurrent counseling. The 4-week continuous abstinence rate at the primary endpoint (Weeks 9 to 12) was significantly (OR, 6.11; 95% CI, 4.18 to 8.93; p\u0026lt;0.0001) higher for varenicline-treated subjects (47.0%) compared with placebo-treated subjects (13.9%; \u003Ca id=\u0022xref-fig-5-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F5\u0022\u003EFigure 5\u003C\/a\u003E). Abstinence rates for the varenicline-treated group were also significantly (p\u0026lt;0.0001) higher at Weeks 9 to 24 (28.2% vs 9.5%), and Weeks 9 to 52 (19.2% vs 7.2%). The 7-day point prevalence of abstinence rose over the 12 weeks of treatment for varenicline, and remained significantly (p\u0026lt;0.0001) elevated relative to placebo during and after drug treatment. The most frequent AEs in the varenicline group were nausea, headache, insomnia, vomiting and abnormal dreams. A total of 23 (6.5%) of varenicline-treated subjects experienced a serious AE compared to 21 (6.0%) of the placebo subjects. There were no differences in the number of adjudicated cardiovascular events (7.4% varenicline vs 6.6% placebo), cardiovascular deaths (0.3% vs 0.6%), or all-cause mortality (0.6% vs 1.4%). Though the authors cautioned that these results cannot be generalized for smokers with recent or acute CVD events, they concluded that varenicline has an acceptable safety profile with no evidence of increased risk of cardiovascular events or psychiatric side effects in smokers with stable CVD.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F5\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F5.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Continuous Tobacco Abstinence Rates.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1493281784\u0022 data-figure-caption=\u0022Continuous Tobacco Abstinence Rates.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 5.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F5.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F5.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 5.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/2\/8\/F5.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11563\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 5.\u003C\/span\u003E \n               \u003Cp id=\u0022p-17\u0022 class=\u0022first-child\u0022\u003EContinuous Tobacco Abstinence Rates.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2009 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/9\/2\/8.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmk6p\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmk6p\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}