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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article data from a post hoc analysis of the Effect of rosuvastatin in patients with chronic heart failure [GISSI-HF; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00336336\u0026amp;atom=%2Fspmdc%2F9%2F4%2F20.2.atom\u0022\u003ENCT00336336\u003C\/a\u003E] study, showing only modest evidence of a reduction in atrial fibrillation (AF) in heart failure (HF) patients who were treated with rosuvastatin. The aim of the subanalysis was to assess the effect of n-3 PUFA and rosuvastatin compared with placebo in patients with chronic HF who were not in AF at study entry.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EArrhythmias\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHeart Failure Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EProfessor Aldo Maggioni, MD, ANMCO Research Center, Florence, Italy, presented data from a post hoc analysis of the GISSI-HF (Effect of rosuvastatin in patients with chronic heart failure; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00336336\u0026amp;atom=%2Fspmdc%2F9%2F4%2F20.2.atom\u0022\u003ENCT00336336\u003C\/a\u003E) study, showing only modest evidence of a reduction in atrial fibrillation (AF) in heart failure (HF) patients who were treated with rosuvastatin. The aim of the subanalysis was to assess the effect of n-3 PUFA and rosuvastatin compared with placebo in patients with chronic HF who were not in AF at study entry.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EGISSI-HF was a double-blind, placebo-controlled trial in patients with chronic HF. Patients were randomized to daily treatments of n-3PUFA (1 g) or placebo (n=6975), and to rosuvastatin (10 mg) or placebo (n=4574). Patients were followed for nearly 4 years. Primary endpoints were all-cause mortality or cardiovascular (CV) hospitalizations. The study comprised men and women aged 18 years or older with clinical evidence of HF New York Heart Association class II-IV. Left ventricular ejection fraction (LVEF) was measured within 3 months of enrollment. AF occurrence was defined as the presence of AF on the electrocardiogram (ECG) that was performed at each visit during the trial, AF as a cause of worsening HF, hospital admission, or as an event during hospitalization.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EOf the patients without AF at baseline, a total of 15.0% developed AF during a median follow-up of 3.7 years. AF occurred in 16% of the placebo and 13.9% of rosuvastatin patients with a 13.2% RRR and 2.1% absolute risk reduction. This difference was not significant when an unadjusted analysis (p=0.097; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E) or multivariable analysis that adjusted just for clinical variables (p=0.067) was performed. However, it became significant when an adjustment was made for clinical variables and laboratory examinations (p=0.039) and for clinical variables, laboratory examinations, and background therapies (p=0.038).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/4\/20.2\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Kaplan-Meier Curves for Time to New Onset of AF.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-55279497\u0022 data-figure-caption=\u0022Kaplan-Meier Curves for Time to New Onset of AF.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/4\/20.2\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/4\/20.2\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/9\/4\/20.2\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11357\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EKaplan-Meier Curves for Time to New Onset of AF.\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EMaggioni A et al. \u003Cem\u003EEur Heart J\u003C\/em\u003E 2009. By permission of Oxford University Press.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-6\u0022\u003EPatients who experienced AF during the study were significantly (p\u22640.03) older (aged \u0026gt;70 years) and had higher BMI, systolic blood pressure, heart rate, NYHA class, and percent LVEF than those who did not experience an AF. They also had significantly (p\u0026lt;0.05) higher frequencies of prior admission for HF, previous stroke, history of hypertension, pacemaker, history of paroxysmal AF, chronic obstructive pulmonary disorder, and more drug treatment.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EAlthough this post hoc analysis showed some evidence of rosuvastatin\u0027s superiority over placebo in reducing the occurrence of AF, it should be noted that the trial was not powered to assess the effect of rosuvastatin on AF occurrence. The effect of a statin treatment that is conducted for a longer period of time or in a larger population of patients should be evaluated to confirm the findings of our study.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThe discussant, Professor Harry Crijns, MD, Maastricht University Medical Centre, Maastricht, The Netherlands, agreed that rosuvastatin was not very effective in preventing incidence of AF in this study and suggested that there are a number of unanswered questions, including \u201cwhether statins prevent AF progression and reduce the burden of AF\u201d and \u201cwhether prevention of AF by statins improves CV morbidity\/mortality.\u201d\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EFull article available at: \u003Ca href=\u0022http:\/\/eurheartj.oxfordjournals.org\/cgi\/content\/full\/ehp357\u0022\u003Ehttp:\/\/eurheartj.oxfordjournals.org\/cgi\/content\/full\/ehp357\u003C\/a\u003E.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2009 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/9\/4\/20.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmj61\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmj61\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}