RT Journal Article
SR Electronic
A1 Cunningham, Muriel
T1 Stroke in Sickle Cell Disease: Recent Successes
JF MD Conference Express
YR 2008
FD SAGE Publications
VO 8
IS 1
SP 25
OP 26
DO 10.1177/155989770800800117
UL http://mdc.sagepub.com/content/8/1/25.abstract
AB The reported incidence of all types of stroke in childhood is relatively low, with 2.6 occurring per 100,000 white children and 3.1 per 100,000 in black children [Broderick et al. Child Neurol 1993]. However, additional analyses indicate that children with sickle cell disease (SCD) face a huge relative risk of ischemic stroke compared with a healthy population (RR=220) [Earley et al. Neurology 1998]. Chronic blood transfusion therapy has been employed as secondary prevention of stroke in patients with SCD for over 30 years