RT Journal Article SR Electronic A1 Vinall, Phil T1 New and Old Targets for Acute Intervention: From Science to the Clinic JF MD Conference Express YR 2008 FD SAGE Publications VO 8 IS 1 SP 5 OP 6 DO 10.1177/155989770800800101 UL http://mdc.sagepub.com/content/8/1/5.abstract AB This article discusses the scientific and clinical targets for acute intervention including immunomodulation, the benefits of direct thrombolytic plasmin, the use of activated protein C for chronic neurodegenerative disorders, as well as strategies to modify the endothelial hemostatic-thrombotic balance to treat stroke.