PT - JOURNAL ARTICLE AU - Vinall, Phil ED - Hallenbeck, John TI - New and Old Targets for Acute Intervention: From Science to the Clinic DP - 2008 May 01 TA - MD Conference Express PG - 5--6 VI - 8 IP - 1 4099 - http://mdc.sagepub.com/content/8/1/5.short 4100 - http://mdc.sagepub.com/content/8/1/5.full AB - This article discusses the scientific and clinical targets for acute intervention including immunomodulation, the benefits of direct thrombolytic plasmin, the use of activated protein C for chronic neurodegenerative disorders, as well as strategies to modify the endothelial hemostatic-thrombotic balance to treat stroke.