Summary

Although anti-TNF therapies are established treatments for rheumatoid arthritis (RA), significant proportions of patients do not achieve an adequate response, or become refractory to them. This article presents data from the RADIATE study [NCT00106522], a randomized, double-blind study that investigated the efficacy and safety of treatment with tocilizumab plus methotrexate in patients with moderate to severe RA and a prior history of failed anti-TNF therapy.