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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ESchizophrenia accounts for a significant portion of the global burden of neuropsychiatric disorders. It is often refractory to treatment and relapse due to poor adherence is also common. In addition, treatments for schizophrenia are frequently associated with side effects that can cause serious medical problems, such as cardiovascular disease. Quetiapine is approved for the treatment of schizophrenia and impacts a broad range of symptoms that affect quality of life.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Epsychopharmacology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eschizophrenia clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003ESchizophrenia accounts for a significant portion of the global burden of neuropsychiatric disorders. It is often refractory to treatment and relapse due to poor adherence is also common. In addition, treatments for schizophrenia are frequently associated with side effects that can cause serious medical problems, such as cardiovascular disease. Quetiapine is approved for the treatment of schizophrenia and impacts a broad range of symptoms that affect quality of life.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPeuskens J et al. (NR4\u2013054) reported that patients with stable schizophrenia who were treated with quetiapine ER (400\u2013800 mg\/day) had lower relapse rates (11.7% vs 48.5%) and significantly longer time to relapse versus placebo after 1 year of treatment (HR 0.13; 95% CI 07, 0.26; p\u0026lt;0.001). Loss of symptomatic remission, as defined by the Andreasen Remission Criteria [Andreasen NC et al. \u003Cem\u003EAm J Psychiatry\u003C\/em\u003E 2005], occurred in 16.4% of quetiapine versus 29.9% of placebo patients. Time to loss was significantly shorter with placebo versus quetiapine ER (HR 0.3; (95% CI 0.19, 0.81); p\u0026lt;0.001).\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EIn a similar patient population, Kalai A et al. (NR4\u2013002) reported that quetiapine XR (400, 600, and 800 mg) and IR (400 mg) daily significantly reduced mean PANSS total score from baseline to Week 6 (p\u0026lt;0.01). Quetiapine XR (all doses) also produced a significant reduction in PANSS aggression and hostility scores. These improvements were not dependent on illness severity.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EFalkai P et al. (NR4\u2013027) reported that after 12 weeks of quetiapine (median 600 mg\/day) treatment, 58.3% of patients with acute schizophrenia achieved resolution (defined as \u22643 on each of the 8 items of the PANSS). Significant baseline predictors of resolution included: younger age, having a first episode and shorter duration of episode, paranoid subtype of schizophrenia, lower PANSS-8 total score, and lower severity of CGI-S. A high number of previous hospitalizations, residuum subtype of schizophrenia, alcohol abuse, and concomitant disease predicted non-resolution.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EJ\u00e4rbink K et al. (NR4\u2013058) reported the results of a 12-week cost-utility analysis in patients who switched from another antipsychotic to quetiapine (66% for lack of efficacy; 34% for tolerability), which showed significant QALY gains, irrespective of the reason for the switch. QALY gains were measured using PANSS score, the presence of adverse events, and methods established by Lenert et al. [\u003Cem\u003ESchizophr Res\u003C\/em\u003E 2004; \u003Cem\u003EHealth Qual Life Outcomes\u003C\/em\u003E 2005].\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/3\/14.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmdpd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}