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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EOver 60% of patients with major depressive disorder (MDD) who are treated with standard antidepressant therapy (ADT) do not achieve remission. The efficacy and safety of aripiprazole as adjunctive therapy recently have been demonstrated in patients who had an inadequate response to initial ADT [Berman RM et al. \u003Cem\u003EJ Clin Psychiatry\u003C\/em\u003E 2007; Marcus RN et al. \u003Cem\u003EJ Clin Psychopharmacol\u003C\/em\u003E 2008]. This article discusses posters, presented during the American Psychiatric Association 2008 Annual Meeting, which reported additional analysis of data from the above studies.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Emood disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Epsychopharmacology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EOver 60% of patients with major depressive disorder (MDD) who are treated with standard antidepressant therapy (ADT) do not achieve remission. The efficacy and safety of aripiprazole as adjunctive therapy recently have been demonstrated in patients who had an inadequate response to initial ADT [Berman RM et al. \u003Cem\u003EJ Clin Psychiatry\u003C\/em\u003E 2007; Marcus RN et al. \u003Cem\u003EJ Clin Psychopharmacol\u003C\/em\u003E 2008].\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPosters that were presented during the APA annual meeting reported additional analysis of data from the above studies, which were identical 14-week trials that consisted of an 8-week prospective treatment phase with ADT and a 6-week randomized, placebo-controlled phase in which patients received either adjunct aripiprazole (n=375; mean dose 11.1 mg\/day) or adjunct placebo (n=368). Only patients who failed to achieve an adequate response (\u0026lt;50% reduction on HAM-D17 Total, HAM17 \u2265 14, and CGI-I \u22653) with ADT entered the randomized phase.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003ECarlson BX et al. (NR3\u2013014) reported that patients who were treated with adjunct aripiprazole for 6 weeks experienced a 1.75-kg increase in weight versus 0.38 kg in placebo patients (p\u0026lt;0.001). Common treatment-emergent adverse events that were seen more often in aripiprazole versus placebo patients included akathisia (28.8%), restlessness (12.1%), insomnia (8.1%), fatigue (8.4%), blurred vision (5.7%), and constipation (4.6%). The majority of akathisia events that were experienced was mild\/moderate and rarely led to discontinuation; 52% resolved by the study end and 80% resolved following a dose reduction.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EIn an analysis of difficult-to-treat core symptoms of depression, Nelson JC et al. (NR3\u2013022) reported that adjunctive aripiprazole produced significantly greater improvement in loss of interest (p=0.0001) and lack of energy (p=0.015) but not motor retardation (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). Overall composite score for these items, as well as HAM-D17 total score, was significantly improved with aripiprazole versus placebo (\u22121.61 vs \u22121.12; p \u0026lt;0.001 and \u22127.1 vs \u22124.7; p\u0026lt;0.001, respectively).\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EReimherr FW et al. (NR3\u2013039) reported that aripiprazole significantly (p\u0026lt;0.001) improved 8 of 10 MADRS line items, including apparent sadness, reported sadness, lassitude, and inability to feel, as early as 1 week after beginning treatment; pessimistic and suicidal thoughts improved within 2 weeks. Reduced sleep and appetite improved gradually with aripiprazole and reached significance (p\u0026lt;0.001) by Week 6.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/3\/12.1\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Mean Change from Baseline (End of Week 8) to Endpoint (Week 14) in HAM-D Composite Drive Score Items.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-404227068\u0022 data-figure-caption=\u0022Mean Change from Baseline (End of Week 8) to Endpoint (Week 14) in HAM-D Composite Drive Score Items.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/3\/12.1\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/3\/12.1\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/3\/12.1\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/10879\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EMean Change from Baseline (End of Week 8) to Endpoint (Week 14) in HAM-D Composite Drive Score Items.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EFor a subset of patients who were defined as anxious or having atypical depression, Trivedi MH et al. (NR3\u2013074) reported that aripiprazole produced significantly (p\u0026lt;0.05) greater improvement in MADRS total score versus placebo. Response and remission rates also were significantly (p\u0026lt;0.05) higher in the aripiprazole treatment group.\u003C\/p\u003E\n         \u003Cp id=\u0022p-9\u0022\u003ETran QV et al. (NR3\u2013097) presented data that showed that the mean reduction in MADRS total score was significantly greater in patients with MDD who received adjunctive aripiprazole versus placebo (\u22128.67 vs \u22125.73; p\u0026lt;0.001). A subpopulation analysis revealed no treatment-by-subgroup interaction.\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EOverall, adjunctive aripiprazole appears to be an efficacious, safe, and well-tolerated treatment for the core symptoms of depression in patients who are resistant to ADT.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/3\/12.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmdm1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmdm1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}