Summary
A growing consensus links the loss of beta-cell mass with the development of type 2 diabetes mellitus. This article demonstrates that endoplasmic reticulum stress, induced by high levels of saturated free fatty acids, triggers a response that leads to eventual beta-cell apoptosis. This observation suggests one or more new targets for the therapeutic maintenance of beta-cell populations.
- endocrinology
- prevention & screening
- diabetes mellitus
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