Summary

Higher levels of high density lipoprotein cholesterol (HDL-C) have been associated with a reduction in risk of cardiovascular disease, largely through its reverse transport of cholesterol, anti-inflammatory and anti-oxidative properties. CSL-111 is a reconstituted HDL that is similar to native HDL. This article discusses the findings from the Effect of Reconstituted High-Density Lipoprotein on Atherosclerosis: Safety and Efficacy trial [ERASE; Tardif et al. JAMA 2007 doi:10.1001/jama.297.15.jpc70004].