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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n\u003Cp id=\u0022p-1\u0022\u003EArsenic trioxide is an effective and indicated agent for relapsed acute promyelocytic leukemia (APL). A study now demonstrates that arsenic trioxide has clinical benefit for patients with newly diagnosed APL. This article reports findings from the study in which arsenic trioxide was given as consolidation therapy to patients with APL who had complete remission following standard induction therapy.\u003C\/p\u003E\n\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ELeukemia\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EArsenic trioxide is an effective and indicated agent for relapsed acute promyelocytic leukemia (APL). A study now demonstrates that arsenic trioxide has clinical benefit for patients with newly diagnosed APL. Bayard L. Powell, MD, the Comprehensive Cancer Center of Wake Forest University reported findings from the study in which arsenic trioxide was given as consolidation therapy to patients with APL who had complete remission following standard induction therapy.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe study involved 480 adults (15\u201379 years old) and 57 children (\u0026lt;15 years old). Adult patients who had complete or partial remission after induction therapy were randomly assigned to receive two 25-day courses of arsenic trioxide (0.15 mg\/kg\/day) as a first consolidation therapy (followed by standard consolidation therapy; n=243) or to receive standard consolidation therapy (n=237). Children received the same induction therapy and standard consolidation therapy; arsenic trioxide was not offered to children because its safety had not been defined in this population at the time of accrual to the study. Data on children were analyzed separately.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe estimated 3-year event-free survival rate was significantly better for patients who received consolidation therapy with arsenic trioxide (81% vs 66%; p=0.0007). The estimated overall survival rate was also significantly better for this group of patients (86% vs 79%; p=0.063). The 3-year event-free and overall survival rates for the group of children were not significantly different from those for adults who did not receive arsenic trioxide (62% and 86%, respectively).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe response rate was similar for all patients (adults and children). Dr. Powell noted that the rate of complete remission was significantly lower for patients who had high-risk disease (defined as a white blood cell count of more than 10,000) compared with the rate for patients with low- or intermediate-risk disease. In addition, the rate of death during induction and the relapse rate (within 1 year) were higher for patients with high-risk APL. \u201cThere were a substantial number of early events during induction, but once patients achieved remission, the shapes of the curves are similar for all three groups,\u201d Dr. Powell explained.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EDr. Powell said that treatment with arsenic trioxide was associated with acceptable toxicity. Grade 4 hematological toxicity occurred during consolidation therapy in 55% of patients treated with arsenic trioxide and in 67% of patients who received only standard consolidation therapy. Grade 4 nonhematological toxicity occurred in 5% of patients in both groups.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2007 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/7\/3\/12.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzma01\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}