RT Journal Article
SR Electronic
A1 Jacobson, Anne
T1 Pharmacogenetic-Guided Dosing of Warfarin: Results of the Couma-Gen Study
JF MD Conference Express
YR 2007
FD SAGE Publications
VO 7
IS 7
SP 18
OP 18
DO 10.1177/155989770700700711
UL http://mdc.sagepub.com/content/7/7/18.1.abstract
AB More than 2 million patients in the United States take warfarin as anticoagulant therapy. The dose of warfarin may vary depending on patient genotypes, which has resulted in changes in the prescribing guidelines for this agent. The effect of pharmacogenetic (PG)-guided dosing, however, has not been established in controlled studies. The Couma-Gen study was a prospective, randomized, double-blind trial of a PG-guided algorithm for warfarin dosing compared with standard dosing in patients starting oral anticoagulation therapy [Anderson JL, Horne BD, Stevens SM et al. Circulation 2007].