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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EIntensive treatment with MTX can increase the number of patients responding to treatment. In a two-year study conventional and intensive MTX treatment strategies were compared in the treatment of patients with early RA using a computer assisted program.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Erheumatology clinical trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Erheumatoid arthritis\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EIntensive treatment with MTX can increase the number of patients responding to treatment. In a two-year study conventional and intensive MTX treatment strategies were compared in the treatment of patients with early RA using a computer assisted program. In the conventional strategy, patients came to the outpatient clinic once every 3 months and were given an adjusted MTX dose based on daily practice.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EIn the intensive strategy, patients came to the clinic monthly and were given an adjusted dose of MTX tailored to the individual, aimed for remission, and based on predefined criteria (\u0026gt;20% improvement from the previous visit for the number of swollen joints, number of tender joints, ESR and VAS general well-being). In both groups, starting dose of MTX was 7.5 mg\/wk and could be increased up to 30 mg\/wk, if needed.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe computer program, used to determine the clinical response, was also evaluated in this study.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EThe endpoint of the study was the number of patients in remission defined as no swollen joints plus 2 out of 3 of the following criteria: number of tender joints \u2264 3, ESR \u2264 20 mm\/hr1st, and VAS general well-being \u2264 20 mm fulfilled at three subsequent visits measured at three monthly intervals.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003ESixty-three (41%) of the patients in the intensive strategy group achieved remission for at least 6 months versus 24% of the patients in the conventional strategy group (p= 0.002). Mean time until first remission was 10 months for the intensive strategy group compared with 13 months for conventional strategy group. Median (IQ 0.25\u20130.75 range) AUC of all clinical variables were significantly better for the intensive strategy group when compared to the conventional strategy group.\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003ETailoring the MTX treatment to the individual patient is significantly more beneficial than the conventional approach. Furthermore, a computer assisted approach, to make more objective decisions on dosage changes, may be beneficial.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/3\/16.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm5dd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}