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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody, was examined as a monotherapy in patients with active RA who had inadequate responses to MTX. In this Japanese study, RA patients previously treated with MTX received either tocilizumab 8 mg\/kg every 4 weeks + a MTX placebo (tocilizumab group) or a tocilizumab placebo + MTX 8 mg\/week (MTX group) for 24 weeks.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Erheumatoid arthritis clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EThe efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody, was examined as a monotherapy in patients with active RA who had inadequate responses to MTX. In this Japanese study, RA patients previously treated with MTX received either tocilizumab 8 mg\/kg every 4 weeks + a MTX placebo (tocilizumab group) or a tocilizumab placebo + MTX 8 mg\/week (MTX group) for 24 weeks. Study endpoints included ACR20, 50, and 70 improvement rates, DAS28, EULAR response, and the numeric index of ACR response (ACR-N) area under the curve (AUC) at 24 weeks.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EThere were 61 patients in the tocilizumab group and 64 patients in the MTX group. After 24 weeks of treatment, ACR20 (80.3% vs 25.0%, p\u0026lt;0.001), ACR50 (49.2% vs 10.9%, p\u0026lt;0.001), and ACR70 (29.5% vs 6.3%, p\u0026lt;0.001) response rates were significantly higher in the tocilizumab group than in the MTX group. Consistent improvements were observed in the EULAR response criteria as well as ACR-N AUC index.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EFewer patients withdrew from the tocilizumab group (n = 7) compared with the MTX group (n = 31) indicating a greater tolerance for tocilizumab. The safety profiles of the two groups were similar. The most common adverse event was nasopharyngitis in both groups (tocilizumab 18.0% and MTX 10.9%).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EThis study indicates that tocilizumab is an efficacious and safe treatment in RA patients with inadequate response to MTX.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/3\/14.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm5dd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}