RT Journal Article
SR Electronic
A1 Alexander, Walter
T1 PPARs in Diabetes and Cardiovascular Disease
JF MD Conference Express
YR 2006
FD SAGE Publications
VO 6
IS 5
SP 22
OP 33
DO 10.1177/155989770600600512
UL http://mdc.sagepub.com/content/6/5/22.abstract
AB Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that control the transcription of several genes involved in lipid and carbohydrate metabolism. Synthetic PPAR agonists have been shown to target some of the maladies in persons that are at extremely high risk for coronary artery disease, such as type 2 diabetes and the metabolic syndrome. These agents have clear anti-atherosclerotic effects by increasing insulin sensitivity and lowering triglyceride levels. Due to their wide-ranging effects, however, elucidation of their overall mechanism and clinical relevance remains a challenge.