RT Journal Article SR Electronic A1 O'Loughlin, Taryn T1 Results of the TOSCA-2 Trial: PCI Maintains Patency but has no Effect on LVEF JF MD Conference Express YR 2006 FD SAGE Publications VO 6 IS 5 SP 15 OP 16 DO 10.1177/155989770600600507 UL http://mdc.sagepub.com/content/6/5/15.2.abstract AB This article discusses the results of the Total Occlusion Study of Canada [TOSCA]-2, which was a mechanistic sub-study of the Occluded Artery Trial [OAT] funded by the National Institutes of Health. Observational studies have suggested beneficial effects of opening a persistently occluded infarct related artery so called “open artery hypothesis,” and the TOSCA-2 study set out to determine the effects of stent-based interventions 3 to 28 days post-myocardial infarction.