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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EPatients with type 2 diabetes are at greater risk for cardiovascular events, and thiazolidinediones, approved for the management of type 2 diabetes, have demonstrated an atheroprotective effect in animal models of atheroscleroisis. The CHICAGO study sought to further elucidate the potential protective effect of the thiazolidinedione pioglitazone in patients with type 2 diabetes.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Ecardiology clinical trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Elipid disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ediabetes mellitus\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EPatients with type 2 diabetes are at greater risk for cardiovascular (CV) events, and thiazolidinediones, approved for the management of type 2 diabetes, have demonstrated an atheroprotective effect in animal models of atheroscleroisis. The CHICAGO study sought to further elucidate the potential protective effect of the thiazolidinedione pioglitazone in patients with type 2 diabetes. This study was conducted at multiple centers in the city of Chicago and enrolled an ethnically and racially diverse population that had adequate control of their cardiac risk factors. Patients were treated for 72 weeks with either pioglitazone (15 to 45 mg daily) or another diabetes medication, glimepiride (1 to 4 mg daily). The primary endpoint was the change in mean posterior wall carotid intima-media thickness (CIMT) from baseline to the final evaluation. The CIMT is a validated surrogate marker of CV risk, as thickening of the CIMT correlates with a higher risk of CV events. The CIMT measurements in the CHICAGO study, taken at baseline, 24, 48 and 72 weeks, were performed at a single center with a single reader in order to minimize the variability of study results.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EA total of 462 patients were randomized in the trial, 232 to pioglitazone and 230 to glimepiride. There were no statistically significant differences in the baseline demographic characteristics of the participants. The mean change in the posterior wall CIMT was 0.771 mm for pioglitazone, compared to 0.779 mm for glimepiride (p=0.017), indicating that the CIMT thickened more in the glimepiride group. The magnitude of the effect was somewhat smaller than that observed in prior trials and with inherent variability in CIMT measurements might not be clinically significant, although it was shown to be statistically significant. The mean change in maximal CIMT (a secondary measure) was also significantly better in the pioglitazone group (p\u22640.01). The observed treatment difference increased over time. Patients in the pioglitazone group also had better HbA1c (p\u22640.05), HDL cholesterol (p\u0026lt;0.0001) and triglycerides (p\u0026lt;0.001) when compared to glimepiride at Week 72. The change is CIMT was not adjusted for effects on HbA1c or HDL levels. No significant changes were observed in LDL cholesterol or systolic blood pressure. Protocol subgroup analyses did not reveal any differences when factors such as age, gender, presence of hypertension, number of years with diabetes, obesity, glucose control, or cholesterol lowering agent use were considered.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThere were four adjudicated first CV events in the pioglitazone group, versus 10 in the glimepiride group. The most common adverse events associated with pioglitazone were edema and weight gain, with one case of congestive heart failure in the pioglitazone group. The data do not warrant treating pre-diabetic patients at this point in the research process, however \u201cpioglitazone may be part of a novel strategy to reduce residual CV risk in patients with type 2 diabetes\u201d concluded Dr. Theodore Mazzone, University of Illinois, Chicago. The results of the CHICAGO trial were published online on November 13, 2006 in JAMA (\u003Ca href=\u0022http:\/\/www.jama-ama-assn.org\u0022\u003Ewww.jama-ama-assn.org\u003C\/a\u003E; Mazzone et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2006; 296; DOI 10.1001\/jama.296.21.joc60158).\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/5\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm4g1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}