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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ESubstituting protein or monounsaturated fats for carbohydrates in a healthy diet will reduce heart disease risk, according to the OmniHeart Collaborative Research Group.\u003C\/p\u003E\n            \u003Cp id=\u0022p-2\u0022\u003EOmniHeart compared the effects of three healthy diets on blood pressure and cholesterol levels in 164 adults with elevated blood pressure \u2013 systolic of 120\u2013159 mm\/Hg or diastolic at 80\u201399 mm\/Hg.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Eclinicla trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecoronary artery disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eprevention\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-3\u0022\u003ESubstituting protein or monounsaturated fats for carbohydrates in a healthy diet will reduce heart disease risk, according to the OmniHeart Collaborative Research Group.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EOmniHeart compared the effects of three healthy diets on blood pressure and cholesterol levels in 164 adults with elevated blood pressure \u2013 systolic of 120\u2013159 mm\/Hg or diastolic at 80\u201399 mm\/Hg.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003E\u201cWhile we know that lowering dietary saturated fat reduces cardiovascular risk, there is less certainty about which macronutrient balance offers optimum risk reduction,\u201d said Dr. Lawrence J. Appel, a principal investigator of OmniHeart and professor of medicine at Johns Hopkins University.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003E\u201cOmniHeart offers evidence that substituting carbohydrates with protein or with unsaturated fat can lower blood pressure, improve cholesterol levels, and reduce heart disease risk.\u201d\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EAll diets were low in saturated fat and healthier than the average diet prior to start of the study. One diet was rich in carbohydrates and is essentially similar to the Dietary Approaches to Stop Hypertension (DASH) diet which emphasizes fruits, vegetables, and low-fat or fat-free dairy products.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThe second diet shifted 10 percent of its calories to protein, compared to the carbohydrate diet. The third shifted 10 percent of its calories to unsaturated fat, predominantly monounsaturated fat (found in peanuts, olives, and oils such as canola oil). Study participants were randomized to one of the three diets for six weeks at a time.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/15.2\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-982064706\u0022 data-figure-caption=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/15.2\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/15.2\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/15.2\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16073\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-9\u0022\u003E\u201cIn comparison to baseline levels (obtained when participants were eating their own food), all three diets lowered systolic blood pressure by 8.2\u20139.5 mm\/Hg and LDL-C by 11.6\u201314.2 mg\/dL,\u201d Appel said.\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EWhen compared to the carbohydrate diet, the protein diet reduced systolic blood pressure, lowered LDL, and reduced triglycerides by nearly 16mg\/dL. (However, HDL decreased by 1.4 mg\/dL.) The unsaturated fat diet reduced systolic blood pressure and while it had no significant effect on LDL, it raised HDL levels and lowered triglyceride levels.\u003C\/p\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EThe OmniHeart study demonstrated that protein and unsaturated fat diets offer the lowest CHD risk. There was a 16 percent risk reduction in the carbohydrate diet, but nearly 20 percent risk reduction in the unsaturated fat and protein diets.\u003C\/p\u003E\n         \u003Cp id=\u0022p-12\u0022\u003E\u201cOmniHeart provides convincing evidence that the amount of carbohydrates, protein and fat people eat influence risk,\u201d said Appel. OmniHeart data can help policy makers in making public health recommendations, as well as assist clinicians in advising patients. Further information is available at \u003Ca href=\u0022http:\/\/www.omniheart.org\u0022\u003Ewww.omniheart.org\u003C\/a\u003E.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2005 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/5\/1\/15.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzm3ze\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm3ze\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}