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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe gender-based cardiac care gap is real. Women are given lipidlowering medications less often than men, are more likely to get an excess dose of glycoprotein IIb\/IIIa inhibitors and do not get aspirin as often as they should.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary artery disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eprevention\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/22\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1723861850\u0022 data-figure-caption=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/22\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/22\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/5\/1\/22\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16078\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003E\n               \u003Cem\u003EA collection of 5-foot-tall red dress statues was created to build greater awareness of the real-life fight against heart disease in women \u2014 the number 1 killer among women of all ethnic backgrounds. The collection was on display throughout the Dallas Convention Center at this year\u0027s Scientific Sessions.\u003C\/em\u003E\n            \u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-2\u0022\u003EThe gender-based cardiac care gap is real. Women are given lipidlowering medications less often than men, are more likely to get an excess dose of glycoprotein IIb\/IIIa inhibitors and do not get aspirin as often as they should.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EA 2003 AHA survey found that only 43 percent of women realize that heart disease is the leading cause of death among American women. Even physicians often base treatment choices on the mistaken belief that women are at a lower risk for cardiac disease than men. Worldwide, heart disease is the number one killer of women of all ethnic backgrounds.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003E\u201cWhen we adjust for that knowledge error, treatment patterns are similar for men and women,\u201d said Alice Jacobs, MD, immediate-past president of the American Heart Association and a Boston University researcher. \u201cIt is clear that we need to focus on education.\u201d\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EThis panel advised physicians to begin treating women more aggressively for heart disease. Reena Bhargava, MD, Kaiser Permanente Northern California, found that women are less likely to receive lipid-lowering medications than men and less likely to reach the ideal LDL cholesterol goal of less than 100 mg\/dL.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003E\u201cThis is an action call for the care of all women,\u201d Dr. Bhargava said. \u201cThe evidence is solid that lipid lowering therapy reduces the morbidity and mortality associated with heart disease.\u201d Her study followed 87,730 patients with heart disease from 1999 to 2003. Just 58 percent of women received lipid-lowering therapy compared to 67 percent of men. Only 65 percent of women in the study achieved their LDL goal of than 100 mg\/dL, versus 78 percent of men.\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EOn the positive side, a meta-analysis by David Brown, MD, SUNY Health Science Center, Stony Brook, NY, found that aspirin lowered the risk of primary stroke in women by 17 percent and the risk of ischemic stroke by 24 percent. There was no change in risk for hemorrhagic stroke.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EAt Duke University, Jeffrey Berger, MD, found that aspirin can reduce mortality in postmenopausal women with cardiovascular disease. The study found no significant difference in protection from 81 mg and 325 mg dosages, but fewer than half of women took either formulation.\u003C\/p\u003E\n         \u003Cp id=\u0022p-9\u0022\u003E\u201cOverall, women are less likely to be treated with aspirin when indicated,\u201d said Dr. Berger. \u201cWe think all women with CVD should be on aspirin.\u201d\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EBecause women are at greater risk of bleeding, some physicians are reluctant to use glycoprotein IIb\/IIIa inhibitors in women following non-ST-elevation acute coronary syndrome (NSTE ACS).\u003C\/p\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EThe risk is real, said Karen Alexander, MD, from Duke Clinical Research Institute in Durham, NC, because women are more likely to get too much of the drug. A study of more than 14,000 NSTE ACS patients found that women are three times more likely to receive an excess dose of GP IIb\/IIIa inhibitors.\u003C\/p\u003E\n         \u003Cp id=\u0022p-12\u0022\u003EGP IIb\/IIIa needs to be downwardly adjusted in patients with moderate to severe renal insufficiency. Weight, age, serum creatinine and gender are all factors contributing to renal insufficiencies, and women have 15% lower creatinine clearance due to gender alone. Women with heart disease tend to be older and of a lower body weight and therefore prone to higher rates of renal insufficiency and consequently are more likely to be overdosed.\u003C\/p\u003E\n         \u003Cp id=\u0022p-13\u0022\u003EPhysicians can reduce major events by dosing more appropriately based on renal status, Dr. Alexander added.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2005 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/5\/1\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzm3c1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm3c1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}