<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Parry, Nicola</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Hurvitz, Sara A.</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">No Survival Benefit When Adding Everolimus to Trastuzumab and Paclitaxel in Advanced HER2-Positive BC</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">11-12</style></pages><abstract><style  face="normal" font="default" size="100%">The BOLERO-1 phase 3 clinical trial demonstrated that adding everolimus to weekly trastuzumab and paclitaxel, as first-line therapy, did not improve progression-free survival in women with previously untreated human epidermal growth factor receptor-2-positive advanced breast cancer. PFS was increased by 7 months with everolimus therapy in the HR-negative subgroup; however, this did not cross the statistical significance threshold. Increased adverse events were also reported in the everolimus-treated group, as well as on treatment, AE-related deaths.</style></abstract><number><style face="normal" font="default" size="100%">56</style></number><volume><style face="normal" font="default" size="100%">14</style></volume></record></records></xml>