PT  - JOURNAL ARTICLE
AU  - Bittner, Dennis
ED  - Slotman, Ben
TI  - TRT in Addition to PCI Improves Outcomes for ES-SCLC
DP  - 2014 Dec 01
TA  - MD Conference Express
PG  - 9--10
VI  - 14
IP  - 31
4099  - http://mdc.sagepub.com/content/14/31/9.2.short
4100  - http://mdc.sagepub.com/content/14/31/9.2.full
AB  - Prophylactic cranial irradiation in the treatment of extensive-stage small cell lung cancer has proven value in reducing symptomatic brain metastases and in improving overall survival at 1 year. However, persistent intrathoracic disease occurs in 76% of such patients and intrathoracic disease progresses in almost 90% of this group. This article discusses data from the Chest Radiotherapy Extensive Stage Trial [CREST; NTR1527] that evaluated the use of thoracic radiotherapy in addition to PCI for treatment of ES-SCLC to prevent occurrence of thoracic disease and halt its progression.