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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EDue to the poor prognosis of recurrent head and neck squamous cell carcinoma (HNSCC), there is an imperative to identify a safe and tolerable therapy course. Despite the prevalence of combined radiotherapy and chemotherapy, an optimal therapeutic regimen has not been elucidated. This article discusses data from a multicenter prospective phase 2 study that looked at concurrent reirradiation and combined chemotherapy treatment for patients with HNSCC.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHead \u0026amp; Neck Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHead \u0026amp; Neck Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EConcurrent reirradiation and combined chemotherapy treatment were tolerable in patients with recurrent head and neck squamous cell carcinoma (HNSCC). Min Yao, MD, PhD, University Hospitals Case Medical Center, Cleveland, Ohio, USA, presented data from a multicenter prospective phase 2 study.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EDue to the poor prognosis of recurrent HNSCC, there is an imperative to identify a safe and tolerable therapy course. Despite the prevalence of combined radiotherapy and chemotherapy, an optimal therapeutic regimen has not been elucidated. This study assessed limited-volume continuous-course intensity-modulated reirradiation (IMRT) and weekly cetuximab with platinum-based chemotherapy.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 46 patients (26% female) with recurrent HNSCC and unresectable tumors or positive margins after surgery participated in this trial. All patients had an Eastern Cooperative Oncology Group performance status of 0 to 1 and previously received radiotherapy for \u0026gt; 6 months without the combination of drugs used in this study.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOver the course of a 7-week period, patients received daily continuous-course IMRT at a dose of 60 to 66 Gy in 30 fractions to the gross tumor volume. During week 1, a loading dose of 400 mg\/m\u003Csup\u003E2\u003C\/sup\u003E of cetuximab was administered. During weeks 2 to 7, concurrent cetuximab (250 mg\/m\u003Csup\u003E2\u003C\/sup\u003E) and cisplatinum (30 mg\/m\u003Csup\u003E2\u003C\/sup\u003E) were applied.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe 1-year overall survival rate was 60%, and at the final follow-up, 27 patients were alive. The 1-year disease-free survival rate was 38%. This therapeutic regimen had a range of grade 1 to 4 acute toxicities, with the most common higher-grade toxicities being lymphopenia, dysphagia, radiation-site dermatitis, mucositis, and anorexia. A single patient discontinued treatment.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003ESome patients experienced local toxicities 90 days after reirradiation, and the highest-grade complication was associated with dysphagia (grade 3). The most common late toxicities were dysphagia, xerostomia, edema, mucositis, fibrosis, and trismus.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThe authors determined that patients with recurrent HNSCC could complete a concurrent reirradiation and chemotherapy trial. Further examination of treatment optimization for this disease stage is necessary.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/31\/12.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm2i1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}