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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ETemozolomide, an oral alkylating agent, has radiosensitizing properties and has demonstrated promise in previous phase 2 studies involving whole-brain radiation therapy. However, these studies did not include sufficient samples of patients with brain metastases from breast cancer, despite the need for improved treatments for such patients. This article discusses data from a phase 2 prospective randomized multicenter study looking at if the addition of TMZ improves the efficacy of WBRT.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBreast Cancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBreast Cancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe addition of temozolomide (TMZ) does not improve the efficacy of whole-brain radiation therapy (WBRT) for the treatment of brain metastases from breast cancer. Kim I. Cao, Institut Curie, Paris, France, and colleagues presented data from a phase 2 prospective randomized multicenter study.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ETMZ, an oral alkylating agent, has radiosensitizing properties and has demonstrated promise in previous phase 2 studies involving WBRT. However, these studies did not include sufficient samples of patients with brain metastases from breast cancer, despite the need for improved treatments for such patients. The present phase 2 trial was intended to determine whether concomitant TMZ with WBRT could improve outcomes for these patients.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients were eligible for this study if they had intra-parenchymal metastases from breast cancer that were newly diagnosed, inoperable, and not suitable for radiosurgery. A total of 100 patients were randomly assigned to 2 treatment groups, one of which received WBRT (3 Gy \u00d7 10 to 30 Gy) alone, while the other received WBRT concomitantly with 75 mg\/m\u003Csup\u003E2\u003C\/sup\u003E\/d of TMZ.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ERadiologic objective response was the primary end point, determined by brain magnetic resonance imaging 6 weeks after the end of treatment. This end point was defined as a partial or complete response based upon World Health Organization-modified criteria. There were multiple secondary end points, including overall survival (OS) and local progression-free survival (PFS). Neurologic symptoms and safety data were also collected.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe primary end point was similar between the 2 study arms; the objective response rates were 30% and 36% for concomitant (WBRT + TMZ) therapy and for WBRT alone, respectively, which was not a significant difference. No patients showed complete response. Neither the median OS nor PFS was statistically significant. The median OS was 11.1 months in the WBRT arm compared with 9.4 months in the concomitant therapy arm. The median PFS was 7.4 months in the WBRT arm compared with 6.9 months in the concomitant therapy arm. The concomitant therapy arm did not show more neurologic improvement than the WBRT arm. Additionally, the concomitant therapy was well tolerated (reversible lymphopenia was the most serious acute toxicity).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe authors concluded that adding TMZ to WBRT did not significantly improve outcomes in patients with brain metastases from breast cancer on the basis of the outcomes studied.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/31\/11.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm24q\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}