PT  - JOURNAL ARTICLE
AU  - Nichols, Emma Hitt
ED  - Cao, Kim I.
TI  - Concomitant TMZ Does Not Improve Effectiveness of WBRT for Brain Metastases from Breast Cancer
DP  - 2014 Dec 01
TA  - MD Conference Express
PG  - 11--11
VI  - 14
IP  - 31
4099  - http://mdc.sagepub.com/content/14/31/11.1.short
4100  - http://mdc.sagepub.com/content/14/31/11.1.full
AB  - Temozolomide, an oral alkylating agent, has radiosensitizing properties and has demonstrated promise in previous phase 2 studies involving whole-brain radiation therapy. However, these studies did not include sufficient samples of patients with brain metastases from breast cancer, despite the need for improved treatments for such patients. This article discusses data from a phase 2 prospective randomized multicenter study looking at if the addition of TMZ improves the efficacy of WBRT.