<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kuznar, Wayne</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Ryan, Charles J.</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Abiraterone Significantly Extends Survival in mCRPC</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">16-17</style></pages><abstract><style  face="normal" font="default" size="100%">Abiraterone acetate as therapy for chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) improved overall survival (OS) compared with placebo in the final OS analysis of the phase 3 COU-AA-302 clinical trial. This article discusses data from more than 4 years of follow-up from the international, randomized, double-blind, placebo-controlled COU-AA-302. Abiraterone is an orally available inhibitor of the CYP17 enzyme complex, a key regulator of androgen synthesis.</style></abstract><number><style face="normal" font="default" size="100%">36</style></number><volume><style face="normal" font="default" size="100%">14</style></volume></record></records></xml>