PT - JOURNAL ARTICLE AU - Kuznar, Wayne ED - Bernards, René TI - Functional Genetic Screens to Find Rational Cancer Drug Combinations Exploit Synthetic Lethality DP - 2014 Dec 01 TA - MD Conference Express PG - 6--7 VI - 14 IP - 36 4099 - http://mdc.sagepub.com/content/14/36/6.short 4100 - http://mdc.sagepub.com/content/14/36/6.full AB - Although combination therapies can help fight therapy resistance when using personalized cancer treatment, the seemingly endless number of possible combinations necessitates strategies to identify rational drug combinations, as discussed in this article.