Functional Genetic Screens to Find Rational Cancer Drug Combinations Exploit Synthetic Lethality

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  • Figure 1.

    Suppression of Colon Cancer Growth by Simultaneously Inhibiting EGFR and BRAF

    Reprinted by permission from Macmillan Publishers Ltd: Nature. Prahallad A et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. 2012;483:100–104. © 2012.