RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 Limited Progress in the Treatment of HCC
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 22
SP 24
OP 26
DO 10.1177/155989771422018
UL http://mdc.sagepub.com/content/14/22/24.abstract
AB The main risk factors for hepatocellular carcinoma (HCC) are hepatitis C virus, hepatitis B virus, and alcohol consumption, which can lead to cirrhosis, genomic instability, and progression to HCC. This process involves a cycle of regeneration and necrosis that induces release of cytokines, proangiogenic factors, and profibrotic factors. Fibrosis and increased cell proliferation can result in formation of a dysplastic nodule, marked genomic instability, loss of p53, and development of HCC [Farazi PA, DePinho RA. Nat Rev Cancer. 2006].