PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Llovet, Josep M.
TI  - Limited Progress in the Treatment of HCC
DP  - 2014 Nov 01
TA  - MD Conference Express
PG  - 24--26
VI  - 14
IP  - 22
4099  - http://mdc.sagepub.com/content/14/22/24.short
4100  - http://mdc.sagepub.com/content/14/22/24.full
AB  - The main risk factors for hepatocellular carcinoma (HCC) are hepatitis C virus, hepatitis B virus, and alcohol consumption, which can lead to cirrhosis, genomic instability, and progression to HCC. This process involves a cycle of regeneration and necrosis that induces release of cytokines, proangiogenic factors, and profibrotic factors. Fibrosis and increased cell proliferation can result in formation of a dysplastic nodule, marked genomic instability, loss of p53, and development of HCC [Farazi PA, DePinho RA. Nat Rev Cancer. 2006].