Summary

This article presented the first year results from the Look AHEAD trial, a large, randomized clinical trial in 5145 obese patients with type 2 diabetes in the United States. The objective is to see if an intensive lifestyle intervention (ILI) to reduce body weight can reduce cardiovascular disease and mortality. The ILI focused primarily on diet (1200–1800 kcal per day based on weight) and exercise (10,000 steps per day, gradual increase to 175 min/week). The control group received routine diabetes support and education consisting of 3 to 4 group meetings per year.