PT  - JOURNAL ARTICLE
ED  - Zile, Michael
ED  - Levy, Dan
ED  - Pfeffer, Marc A.
ED  - Greenberg, Barry
ED  - Carabello, Blase
TI  - Progression from Hypertension to Heart Failure: Mechanisms, Epidemiology, and Prevention
DP  - 2006 May 01
TA  - MD Conference Express
PG  - 27--27
VI  - 6
IP  - 1
4099  - http://mdc.sagepub.com/content/6/1/27.short
4100  - http://mdc.sagepub.com/content/6/1/27.full
AB  - Michael Zile, MD, Medical University of South Carolina, discussed the HTN-HF continuum, focusing on matrix mettalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Research conducted at his own institution measured plasma profiles of MMPs and TIMPs in HF patients and age-matched healthy people. “We know that inflammatory cytokines induce MMP expression in vitro,” Dr. Zile said. The South Carolina investigators detected MMP/TIMP ratios elevated as high as 16-fold in hypertensive patients with HF.