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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EExperts reviewed current issues in interventional cardiology. This review included the present state of transcatheter valve implantation and repair, the optimal duration of dual antiplatelet therapy after percutaneous coronary intervention, whether or not to treat nonculprit coronary artery disease during the index percutaneous coronary intervention in patients with STEMI, and clinical trials of renal denervation.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Ebystander disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Edual antiplatelet therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Einterventional techniques \u0026amp; devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Emyocardial infarction\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Epercutaneous coronary intervention\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Erenal denervation\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Etranscatheter aortic valve replacement\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EExperts at the European Society of Cardiology Congress 2015 discussed recent developments in interventional cardiology, including the state of transcatheter valve interventions, optimal duration of dual antiplatelet therapy (DAPT) following stent placement, treatment options for multivessel disease, and data from the latest renal denervation (RDN) trials.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-2\u0022\u003E\u003Ch2 class=\u0022\u0022\u003ETranscatheter Valve Interventions\u003C\/h2\u003E\u003Cp id=\u0022p-3\u0022\u003ESince the first transcatheter aortic valve replacement (TAVR) procedure in 2002, \u0026gt;\u2005200\u2005000 patients have been treated and multiple valves and delivery systems have been approved for use in clinical care. Alec Vahanian, MD, Paris Diderot \u003Cem\u003EUniversity\u003C\/em\u003E - \u003Cem\u003EParis 7\u003C\/em\u003E, Paris, France, reviewed the current state of TAVR and transcatheter mitral valve repair and replacement.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EFollow-up data indicate that outcomes for high-risk patients with severe aortic stenosis who undergo TAVR are similar to, if not better than, surgical aortic valve replacement [Mack MJ et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2015]. In addition, complication rates and deaths have continued to decrease over time [Walther T et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E. 2015]. Results from the ongoing PARTNER-II [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01314313\u0026amp;atom=%2Fspmdc%2F15%2F28%2F28.atom\u0022\u003ENCT01314313\u003C\/a\u003E] and SURTAVI trials [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01586910\u0026amp;atom=%2Fspmdc%2F15%2F28%2F28.atom\u0022\u003ENCT01586910\u003C\/a\u003E] should provide valuable information in the near future.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAvailable data suggest that transcatheter mitral valve repair using the edge-to-edge technique is safe and improves symptoms in certain high-risk patients. However, additional data from long-term follow-up and randomized trials are needed. Transcatheter mitral valve implantation is feasible, but safety concerns exist and few patients have been treated at this time. There are many challenges facing percutaneous mitral valve replacement, including the positioning, fixation, durability, and retrievability of the valve and developing methods to prevent paravalvular leaks, mitral valve and left ventricular outflow track gradients, and thrombogenicity.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EIn his concluding remarks, Dr Vahanian emphasized the importance of having an experienced heart team and adequate imaging, as these will help determine the optimal procedure and achieve the best outcomes.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-3\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EDAPT After Stent Placement\u003C\/h2\u003E\u003Cp id=\u0022p-7\u0022\u003EMarco Valgimigli, MD, PhD, Swiss Cardiovascular Center, Bern, Switzerland, reviewed several meta-analyses of trials of DAPT duration after percutaneous coronary intervention (PCI). A meta-analysis of 7 randomized controlled trials indicated that DAPT for \u0026lt;\u200512 months was associated with a lower risk of bleeding without increasing ischemic risk; however, the power for detecting a significant difference in ischemic outcomes was limited based on the small number of events (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E) [Valgimigli M et al. \u003Cem\u003EEur Heart J\u003C\/em\u003E. 2015]. Others have reported that for every event of stent thrombosis prevented with prolonged DAPT, about 2.1 events of clinically significant bleeding are expected [Giustino G et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E. 2015]. Another meta-analysis of patients with coronary artery disease (CAD) was conducted, in which the analysis was stratified based on DAPT duration in the control group (\u2264\u200512 or \u0026gt;\u200512 months). Shortening DAPT to \u0026lt;\u20051 year did not significantly impact mortality (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.49); however, prolonged DAPT resulted in significantly higher mortality (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.03) [Navarese EP et al. \u003Cem\u003EBMJ\u003C\/em\u003E. 2015]. Another group conducted a similar meta-analysis using a different statistical approach and found similar results: a 22% increase in mortality with prolonged DAPT (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.02) [Palmerini T et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2015]. These results were in contrast to another large meta-analysis that showed no difference in mortality [Mauri et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2014].\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/28\/28\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Meta-analysis of 7 Randomized Controlled Trials (n\u0026#x2005;=\u0026#x2005;15\u0026#x2005;378)DAPT, dual antiplatelet therapy.Reprinted from Valgimigli M, Ariotti S, Costa F. Duration of dual antiplatelet therapy after drug-eluting stent implantation: will we ever reach a consensus? Eur Heart J, 2015, Vol 36, Issue 20, Pages 1219-1222, by permission of the European Society of Cardiology.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-830880984\u0022 data-figure-caption=\u0022\u0026amp;lt;div xmlns=\u0026amp;quot;http:\/\/www.w3.org\/1999\/xhtml\u0026amp;quot;\u0026amp;gt;Meta-analysis of 7 Randomized Controlled Trials (n\u0026#x2005;=\u0026#x2005;15\u0026#x2005;378)DAPT, dual antiplatelet therapy.Reprinted from Valgimigli M, Ariotti S, Costa F. Duration of dual antiplatelet therapy after drug-eluting stent implantation: will we ever reach a consensus? \u0026amp;lt;em\u0026amp;gt;Eur Heart J\u0026amp;lt;\/em\u0026amp;gt;, 2015, Vol 36, Issue 20, Pages 1219-1222, by permission of the European Society of Cardiology.\u0026amp;lt;\/div\u0026amp;gt;\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/28\/28\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/28\/28\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/28\/28\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16981\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \u003Cp id=\u0022p-8\u0022 class=\u0022first-child\u0022\u003EMeta-analysis of 7 Randomized Controlled Trials (n\u2005=\u200515\u2005378)\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EDAPT, dual antiplatelet therapy.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EReprinted from Valgimigli M, Ariotti S, Costa F. Duration of dual antiplatelet therapy after drug-eluting stent implantation: will we ever reach a consensus? \u003Cem\u003EEur Heart J\u003C\/em\u003E, 2015, Vol 36, Issue 20, Pages 1219-1222, by permission of the European Society of Cardiology.\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-11\u0022\u003EIn contrast, the recently reported randomized PEGASUS-TIMI 54 trial [Bonaca et al. \u003Cem\u003ENew Engl J Med\u003C\/em\u003E. 2015] demonstrated that in \u0026gt;\u200521\u003Cem\u003E\u2005\u003C\/em\u003E000 stable patients with a history of MI 1 to 3 years prior (including patients without coronary stents), prolonged DAPT significantly reduced cardiovascular (CV) death, MI, and stroke. While this strategy increased major bleeding, it did not increase intracranial hemorrhage (ICH) or fatal bleeding and did not increase mortality. These findings were further supported by a recent subanalysis of a randomized DAPT trial focusing on patients with a history of MI and coronary stenting [Yeh R et al. \u003Cem\u003EJ Am Coll Cardio\u003C\/em\u003E. 2015], which showed a reduction in ischemic events without any increase in mortality. Driven by these trials, a meta-analysis presented as a Clinical Trial Update focused on continued DAPT as long-term secondary prevention of ischemic risk in patients with prior MI and found that prolonged DAPT reduced the incidence of ischemic CV events. In particular, prolonged DAPT reduced myocardial infarction, ischemic stroke, and stent thrombosis. Importantly, prolonged DAPT after MI significantly reduced CV death. Prolonged DAPT did increase major bleeding but it did not increase ICH, fatal bleeding, or all-cause mortality [Udell JA et al. \u003Cem\u003EEur Heart J\u003C\/em\u003E. 2015].\u003C\/p\u003E\u003Cp id=\u0022p-12\u0022\u003EDr Valgimigli noted that, with more data becoming available, it has become apparent that the focus should shift from protecting the stent to protecting the patient, and that DAPT duration must be individualized. A recent survey of clinicians indicates that this customization occurs in clinical practice, as \u0026gt;\u200570% of clinicians always account for ischemic and bleeding risk when determining DAPT duration [Valgimigli M et al. \u003Cem\u003EEuroIntervention\u003C\/em\u003E. 2015]. Importantly, as demonstrated by PGASUS-TIMI 54 and the DAPT acute coronary syndrome subgroup, the risk-benefit of prolonged DAPT in patients with prior MI, including those who have never been stented, is more favorable relative to prolonged therapy in patients undergoing coronary stenting for stable disease without prior MI. This may therefore be an important clinical characteristic to guide decision making for clinicians.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-4\u0022\u003E\u003Ch2 class=\u0022\u0022\u003ETreatment Options for Multivessel Disease\u003C\/h2\u003E\u003Cp id=\u0022p-13\u0022\u003EIn patients presenting with STEMI, 30% to 50% will have significant CAD in noninfarct arteries. Andreas Baumbach, MD, University of Bristol, Bristol, United Kingdom, reviewed the current evidence regarding treatment of patients with STEMI and multivessel CAD.\u003C\/p\u003E\u003Cp id=\u0022p-14\u0022\u003EThe treatment strategy for patients with multivessel CAD in STEMI is controversial. Several trials have been conducted to investigate this issue. The PRAMI trial, which was stopped after an interim analysis, found a clear risk reduction of cardiac death, nonfatal MI, or refractory angina in patients having infarct-artery PCI who underwent nonculprit artery PCI to treat all lesions vs patients who did not (HR, 0.35; 95% CI, 0.21 to 0.58; \u003Cem\u003EP\u2005\u003C\/em\u003E\u0026lt;\u2005.001). There was no increase in complications in patients who underwent nonculprit PCI [Wald DS et al. \u003Cem\u003ENew Eng J Med\u003C\/em\u003E. 2013]. In the CvLPRIT trial, a clear benefit in major adverse CV events was also seen with complete revascularization compared with treating the infarct-related artery only (HR, 0.45; 95% CI, 0.24 to 0.84; \u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.009), with no adverse safety findings [Gershlick AH et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E. 2015]. In the DANAMI3-PRIMULTI trial, patients who had undergone infarct-related artery PCI were randomly assigned to either no further invasive treatment or fractional flow reserve-guided complete revascularization [Engstr\u00f8m T et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2015]. Results favored complete revascularization (all-cause mortality, nonfatal MI, ischemia-driven revascularization; HR, 0.56; 95% CI, 0.38 to 0.83; \u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.004).\u003C\/p\u003E\u003Cp id=\u0022p-15\u0022\u003EMultivessel PCI in STEMI is safer now, because of improvements in devices and thrombotics, and is associated with stabilization of multiple ruptured plaques, avoidance of myocardial stunning of the infarct-related artery (IRA), and hibernation or dysfunction of the non-IRA. It also leads to more rapid improvement and complete revascularization through a single procedure. In contrast, multivessel PCI is also associated with an increased risk of procedural complications, including contrast-induced nephropathy, radiation exposure, and ischemia in the non-IRA. Further considerations in balancing the pros and cons include the heightened state of inflammation and thrombosis with multivessel PCI and overestimation of non-IRA lesion severity.\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003EDr Baumbach concluded that he feels \u201cwe cannot leave bystander disease alone.\u201d Staged PCI with a fractional flow reserve-guided approach appears to be safe during an index admission, but effectiveness of a staged PCI within 2 to 4 weeks of the index event remains uncertain.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-5\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EUpdate on RDN Trials\u003C\/h2\u003E\u003Cp id=\u0022p-17\u0022\u003EFelix Mahfoud, MD, University Hospital of Saarland, Homburg\/Saar, Germany, summarized data from 3 recent randomized controlled trials of RDN. In the DENERHTN trial, patients with uncontrolled hypertension were randomly assigned to RDN plus a standardized stepped-care antihypertensive treatment regimen or the treatment regimen alone [Azizi M et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2015]. The study met its primary end point, as patients treated with RDN had larger mean reductions in daytime systolic blood pressure (SBP) from baseline to 6 months (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.03).\u003C\/p\u003E\u003Cp id=\u0022p-18\u0022\u003EIn a study sponsored by the University of Leipzig, patients were randomly assigned to RDN or a sham control [Desch et al. \u003Cem\u003EHypertension\u003C\/em\u003E. 2015]. The intent-to-treat analysis did not show a significant difference between the 2 arms in lowering 24-hour SBP at 6 months (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.15), but RDN was significantly better in a per-protocol analysis that excluded 6 patients (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.042).\u003C\/p\u003E\u003Cp id=\u0022p-19\u0022\u003EThe Prague-15 trial compared RDN with optimal antihypertensive treatment [Rosa J et al. \u003Cem\u003EHypertension\u003C\/em\u003E. 2015]. Both arms had a significant decrease in 24-hour SBP from baseline to 6 months (both \u003Cem\u003EP\u2005\u003C\/em\u003E\u0026lt;\u2005.001), but there was no significant difference between the groups (\u003Cem\u003EP\u2005\u003C\/em\u003E=\u2005.87). A greater proportion of the patients in the pharmacological group experienced adverse events compared with the RDN group (39% vs 23%, respectively).\u003C\/p\u003E\u003Cp id=\u0022p-20\u0022\u003EIn light of the results obtained from the SYMPLICITY HTN-3 trial [Bhatt DL et al. \u003Cem\u003ENew Engl J Med\u003C\/em\u003E. 2014], which failed to show a difference in blood pressure control between RDN and a sham control using a blinded design, a panel of experts gathered and published recommendations regarding the design of future clinical trials of RDN [Mahfoud F et al. \u003Cem\u003EEur Heart J\u003C\/em\u003E. 2015]. This publication offers potential solutions in the areas of medications, patient selection, and procedural considerations as an aid to future research in RDN.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/15\/28\/28.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzl561\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzl561\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}