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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003ETECOS was a large randomized placebo-controlled trial in patients with type 2 diabetes mellitus and cardiovascular disease, conducted to demonstrate the noninferiority of sitagliptin as compared with placebo in the risk of cardiovascular events. A prespecified secondary analysis found no impact of sitagliptin on heart failure hospitalization or related events.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Ecardiovascular outcomes\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eheart failure\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ehospitalization\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Erandomized controlled trial\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Etype 2 diabetes mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Esitagliptin\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EThe TECOS study [Green JB et al. \u003Cem\u003ENew Eng J Med\u003C\/em\u003E. 2015] was a large randomized placebo-controlled trial conducted in patients with type 2 diabetes mellitus (T2DM) and prevalent cardiovascular (CV) disease. Frans Van de Werf, MD, PhD, University of Leuven, Leuven, Belgium, presented the results of a prespecified secondary analysis from this trial.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe objective of the TECOS study was to evaluate CV risk with sitagliptin added to usual care. For the primary composite end point of CV death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization for unstable angina, sitagliptin was noninferior to placebo for CV risk (HR, 0.98; 95% CI, 0.88 to 1.09; \u003Cem\u003EP\u003C\/em\u003E\u2005\u0026lt;\u2005.001).\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients with T2DM and atherosclerosis are at an increased risk of hospitalization for heart failure (HF). Two large clinical trials have suggested that dipeptidyl peptidase-44 inhibitors could increase HF hospitalizations: saxagliptin in the SAVOR-TIMI 53 trial [Scirica BM et al. \u003Cem\u003ENew Eng J Med\u003C\/em\u003E. 2013] and alogliptin in the EXAMINE trial [White WB et al. \u003Cem\u003ENew Eng J Med\u003C\/em\u003E. 2013]. A prespecified secondary analysis of TECOS investigated the potential effects of sitagliptin on hospitalization for HF and associated outcomes in the study population and selected subgroups.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOf the 14\u2005671 patients enrolled in TECOS, 457 (3.1%) had a hospitalization for HF during the study. Baseline characteristics for these 2 groups are presented in \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E. There was no significant difference between sitagliptin and placebo in the time to first hospitalization for HF (HR, 1.00; 95% CI, 0.84 to 1.20; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.95). In addition, no significant risk was noted in selected subgroups of age, sex, body mass index, diabetes duration, HbA\u003Csub\u003E1c\u003C\/sub\u003E, insulin use, renal function, prior coronary artery disease, prior HF, and HF severity.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/16964\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/16964\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16964\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EBaseline Characteristics by Hospitalization for HF\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-10\u0022\u003EThere were also no significant differences in other HF-related outcomes, such as hospitalization for HF or CV death (HR, 1.02; 95% CI, 0.90 to 1.14; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.81), hospitalization for HF or all-cause death (HR, 1.00; 95% CI, 0.90 to 1.11; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.93), and total hospitalization for HF events (first plus recurrent; HR, 1.00; 95% CI, 0.80 to 1.25; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.996). In terms of HF-related outcomes in patients with prior HF at baseline (sitagliptin, n\u2005=\u20051303; placebo, n\u2005=\u20051340), there were no significant differences between treatment groups in hospitalization for HF (HR, 1.03; 95% CI, 0.77 to 1.36; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.86), CV death (HR, 0.91; 95% CI, 0.71 to 1.17; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.46), hospitalization for HF or CV death (HR, 0.96; 95% CI, 0.79 to 1.18; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.71), or all-cause death (HR, 0.92; 95% CI, 0.75 to 1.14; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.46).\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EDr Van de Werf concluded that this prespecified analysis of the TECOS database does not suggest an increased risk of HF or related adverse events with sitagliptin in patients with T2DM and prevalent CV disease. These findings support the use of sitagliptin in these patients without concerns of worsening HF.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/15\/28\/15.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzl4ke\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzl4ke\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}