PT - JOURNAL ARTICLE AU - Zarifyan, Alla ED - Williams, Bryan ED - Brown, Morris J. TI - PATHWAY-2 and -3 DP - 2015 Nov 21 TA - MD Conference Express PG - 12--13 VI - 15 IP - 28 4099 - http://mdc.sagepub.com/content/15/28/12.short 4100 - http://mdc.sagepub.com/content/15/28/12.full AB - PATHWAY-2 and PATHWAY-3 demonstrated that potassium-sparing diuretics are safe and effective for the treatment of hypertension. Spironolactone was significantly more effective in controlling resistant hypertension than doxazosin or bisoprolol, whereas the amiloride/HCTZ combination neutralized the undesirable changes in blood glucose and potassium while significantly lowering blood pressure.