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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EA novel software program has been developed to diagnose arrhythmogenic right ventricular dysplasia\/cardiomyopathy at an earlier stage so better reduce the risk of sudden cardiac death. The investigational work supporting this software is reviewed in this article.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Earrhythmogenic right ventricular dysplasia\/cardiomyopathy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EARVC\/D\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Esudden cardiac death\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecardiology \u0026amp; cardiovascular medicine screening \u0026amp; prevention\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EA novel methodology that performs 3D vector analyses of electrocardiograms to better determine the risk of sudden cardiac death (SCD) from arrhythmogenic right ventricular dysplasia\/cardiomyopathy (ARVD\/C) was developed and reviewed by Ivana I. Vranic, MD, PhD, University Clinical Center of Serbia, Belgrade, Serbia, in the European Heart Rhythm Association\/Cardiostim Inventors Awards session. The objective of her work was to diagnose ARVC\/D before it is manifest and traditional markers are observable and to follow disease progression.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EARVC\/D is an inherited disease of the heart muscle that leads to ventricular arrhythmias because of electrical instability and to ventricular tachycardia and fibrillation that can cause SCD, particularly during sports activity. Furthermore, patients with ARVC often present with cardiac arrest or advanced heart failure, and early detection might help patients receive primary prevention and treatment for heart failure.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EEarly work by Prof Vranic included the observation and discovery of the V sign (formed by the confluence of the ductus arteriosus and aortic isthmus) on echocardiography as a characteristic specific to ARVC\/D and the development of the ability to identify the Tau point on echocardiography. The Tau point is the specific location in the heart with the strongest influence of orthogonally opposed forces during the cardiac cycle and the location of early-induced apoptosis. Radionuclide ventriculography was used to verify the presence of ARVC\/D in the silent phase; these patients had very low regional and global ejection fractions in the right ventricle compared with the left ventricle.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe novel software, called VCG Sophie, incorporates these findings and was evaluated in patients in an ARVC\/D database established by Prof Vranic in Serbia. Vectorcardiography was discovered by the presence of the V sign and T sign, stated Prof Vranic. Data from 36 patients who had ongoing monitoring with echocardiography that measured subtle changes with 2D vector loops were analyzed with 3D vector analysis.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe VCG Sophie software has proven to be a powerful tool with a 90% sensitivity and 100% specificity to diagnose ARVC\/D. Notably, this software can be used in any medical office in the world, stated Prof Vranic, and will be especially useful in those that do not have echocardiography and other technology. This software will allow for earlier diagnosis of ARVC\/D and the prevention of SCD because of earlier treatment, concluded Prof Vranic.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/15\/22\/13.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzl3ve\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}