Summary

Vitamin D deficiency has been linked to cardiovascular events and mortality, infection, and autoimmune disorders. Deficiency of 25-hydroxyvitamin D [25(OH)D] <30 ng/mL occurs in about 80% of patients undergoing dialysis. The double-blind, placebo-controlled Safety and Effects of Supplementation With Ergocalciferol on Erythropoietin Dosing in Hemodialysis Patients [NCT01395823] trial investigated the safety and effects of dosing on dialysis patients, as discussed in this article.