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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ELumbar arthrodesis for the treatment of low back pain from degenerative disc disease (DDD) in patients for whom medical therapy is not successful remains controversial. This article presents the results of the Functional Outcomes After Lumbar Spine Fusion Between Patients With Spondylolisthesis and Those With Degenerative Disc Disease study that evaluated the 2-year change in patient-reported outcomes after lumbar arthrodesis for DDD and patient-reported outcomes after lumbar arthrodesis between patients with grade 1 spondylolisthesis and DDD.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ESpine Conditions Orthopaedics Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedic Procedures\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ESpine Conditions\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedics\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedics Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedic Procedures\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003ELumbar arthrodesis for the treatment of low back pain from degenerative disc disease (DDD) in patients for whom medical therapy is not successful remains controversial. Previous work has suggested that the outcomes of lumbar fusion for low back pain from DDD are inferior to those in patients with a condition with instability, such as spondylolisthesis. Owoicho Adogwa, MD, Duke University, Durham, North Carolina, USA, presented the results of the Functional Outcomes After Lumbar Spine Fusion Between Patients With Spondylolisthesis and Those With Degenerative Disc Disease study [Moojen W et al. \u003Cem\u003ESpine\u003C\/em\u003E. 2014] that evaluated the 2-year change in patient-reported outcomes after lumbar arthrodesis for DDD and patient-reported outcomes after lumbar arthrodesis between patients with grade 1 spondylolisthesis and DDD.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EThe nationwide, multicenter study included a total of 1741 patients, 1031 with DDD and 636 with grade 1 spondylolisthesis. Patient demographics were similar in both groups. They were aged an average of 55 years, and the body mass index was about 30 kg\/m\u003Csup\u003E2\u003C\/sup\u003E. A higher proportion of men were diagnosed with DDD than with grade 1 spondylolisthesis (53.70% vs 37.94%, \u003Cem\u003EP\u003C\/em\u003E = .056).\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe study included patients aged between 18 and 70 years with low back pain or radiculopathy, and evidence of DDD or grade 1 spondylolisthesis on magnetic resonance imaging. Exclusion criteria were prior back surgery; severe coexisting pathology, including rheumatoid arthritis, osteoarthritis, or metabolic bone disease; and involvement in an active lawsuit for medical or workers\u0027 compensation.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EInvestigators prospectively collected data between January 2003 and December 2010 in a multicenter registry on patient and surgical variables, pain measures, and functional status in patients undergoing lumbar interbody fusion for a primary diagnosis of grade 1 spondylolisthesis or DDD. This is a retrospective analysis of this database.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EAt the 1- and 2-year follow-up, there were comparable improvements in the visual analog score for back pain and the Oswestry Disability Index scores in the DDD and spondylolisthesis groups (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E).\u003C\/p\u003E\n         \u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/15380\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/15380\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15380\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EPatient-Reported Outcomes at 1 and 2 Years After Surgery\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EThe study also found that significantly more patients with grade 1 spondylolisthesis had a postsurgical pulmonary embolism or deep vein thrombosis compared with patients with DDD (6 vs 0; \u003Cem\u003EP\u003C\/em\u003E = .014), and needed a reoperation (19 vs 8; \u003Cem\u003EP\u003C\/em\u003E = .001). No difference was found between the 2 groups for other complications.\u003C\/p\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EThe authors concluded that in patients with symptomatic DDD, lumbar arthrodesis provided significant improvement in low back pain and functional disability, and thus should be considered a viable option for patients whose back pain has not been treated successful with medical therapy.\u003C\/p\u003E\n         \u003Cp id=\u0022p-12\u0022\u003E\n            \u003Cem\u003EScientific Advisor Note\u003C\/em\u003E: The patient demographics for the 2 groups were not presented. The higher rate of thromboembolic events in the spondylolisthesis group may be explained by differences in the demographics, such as being older or having more comorbidities, compared with the DDD group. Furthermore, the conclusions by these authors must be balanced against previous results from other studies demonstrating comparable outcomes between operative and nonoperative treatment, and against the fact that this study compared 2 different diagnoses, not 2 different treatments.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/50\/18.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzltc2\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzltc2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}