RT Journal Article SR Electronic A1 Vinall, Maria T1 TARGET JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 9 SP 7 OP 7 DO 10.1177/1559897715588276 UL http://mdc.sagepub.com/content/15/9/7.1.abstract AB Treatment with AVP-825 significantly reduces headache-associated burden and functional disability. Improvements are seen as early as 45 minutes after treatment, with significant percentages of patients reporting either mild or no disability by 120 minutes postdose. Headache response, improvement in functioning, and reduction in disability corresponded with the rates of patient-reported meaningful relief.