RT Journal Article SR Electronic A1 Buckley, Rita T1 Optimal Dosing and Titration of U-500R Improve Glycemic Control JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 4 SP 8 OP 8 DO 10.1177/1559897715581821 UL http://mdc.sagepub.com/content/15/4/8.1.abstract AB Human regular U-500 insulin (U-500R) is more concentrated and has a higher potency level than U-100 insulin. Dosing errors can occur in patients on concentrated insulin. This study investigates dosing and titration of U-500R insulin using a twice- or thrice-daily dosing schedule.