RT Journal Article SR Electronic A1 Vinall, Maria T1 Compliance Higher With Once-Daily Antibiotic Administration vs Multiple Times a Day JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 48 SP 21 OP 21 DO 10.1177/1559897715591530 UL http://mdc.sagepub.com/content/15/48/21.abstract AB A number of small studies have indicated that once-daily administration of an antibiotic is just as effective as multiple daily doses. In this meta-analysis using studies in adults and children, the relative risk for compliance with antibiotic treatment was higher with once-daily dosing compared with dosing two, three, or four times daily.