Summary

Pooled data from RECLAIM 1 and 2 found that a new combination of antibiotics, incorporating ceftazidime plus avibactam plus metronidazole, was noninferior to meropenem in patients with complicated intra-abdominal infections, with no known safety signals. At the dose studied, the combination was less effective than meropenem to patients with renal impairment at baseline; however, new dosing recommendations are likely to remediate this.