RT Journal Article SR Electronic A1 Mosley, Mary T1 Left Atrial Appendage Closure and Stroke Prevention JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 10 SP 13 OP 14 DO 10.1177/1559897715591144 UL http://mdc.sagepub.com/content/15/10/13.abstract AB Mechanical closure of the left atrial appendage reduces the stroke event rate in patients with nonvalvular atrial fibrillation and appears to be an alternative to medical therapy with an oral anticoagulant. The Lariat and Watchman devices are among the current options, and next-generation devices are being developed to address design issues to further improve clinical outcomes and safety.