RT Journal Article SR Electronic A1 Zarifyan, Alla T1 Current Approaches, Challenges, and Opportunities in CV Clinical Research JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 10 SP 2 OP 3 DO 10.1177/1559897715591148 UL http://mdc.sagepub.com/content/15/10/2.abstract AB A shifting scientific paradigm in disease understanding and management is leading to a systems approach where diseases are modeled in an interactome that consolidates all molecular interactions within a cell. This approach can lead to a systematic understanding of the molecular mechanisms underlying a complex disease and aid in successful treatment.