PT - JOURNAL ARTICLE AU - Zarifyan, Alla ED - Loscalzo, Joseph ED - Harrington, Robert A. TI - Current Approaches, Challenges, and Opportunities in CV Clinical Research DP - 2015 Jul 25 TA - MD Conference Express PG - 2--3 VI - 15 IP - 10 4099 - http://mdc.sagepub.com/content/15/10/2.short 4100 - http://mdc.sagepub.com/content/15/10/2.full AB - A shifting scientific paradigm in disease understanding and management is leading to a systems approach where diseases are modeled in an interactome that consolidates all molecular interactions within a cell. This approach can lead to a systematic understanding of the molecular mechanisms underlying a complex disease and aid in successful treatment.