RT Journal Article SR Electronic A1 Parry, Nicola T1 Emerging Approaches in the Treatment of Depression JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 11 SP 15 OP 16 DO 10.1177/1559897715593513 UL http://mdc.sagepub.com/content/15/11/15.abstract AB This article discusses promising strategies in the management of treatment-resistant major depressive disorder. These include the use of pharmacologic approaches to modulate the hypothalamic-pituitary-adrenal axis, glutamatergic system, and endogenous opioid system, as well as nonpharmacologic approaches such as deep brain stimulation.