PT - JOURNAL ARTICLE AU - Parry, Nicola ED - Schatzberg, Alan F. TI - Emerging Approaches in the Treatment of Depression DP - 2015 Sep 11 TA - MD Conference Express PG - 15--16 VI - 15 IP - 11 4099 - http://mdc.sagepub.com/content/15/11/15.short 4100 - http://mdc.sagepub.com/content/15/11/15.full AB - This article discusses promising strategies in the management of treatment-resistant major depressive disorder. These include the use of pharmacologic approaches to modulate the hypothalamic-pituitary-adrenal axis, glutamatergic system, and endogenous opioid system, as well as nonpharmacologic approaches such as deep brain stimulation.