RT Journal Article
SR Electronic
A1 Hoyle, Brian
T1 Naldemedine Effective at Relieving Opioid-Induced Constipation
JF MD Conference Express
YR 2015
FD SAGE Publications
VO 15
IS 14
SP 11
OP 11
DO 10.1177/1559897715593921
UL http://mdc.sagepub.com/content/15/14/11.abstract
AB A phase 2b randomized, double-blind, placebo-controlled study shows that naldemedine, a peripherally acting µ-opioid receptor antagonist, is effective in easing opioid-induced constipation compared to placebo. Phase 3 development is expected for the 0.2 mg/day naldemedine dose.