Summary

Multivariate analysis shows that > 2000 patients with hepatitis C virus who received 3 direct-acting antivirals and had <4 predictors of negative response experienced 12-week sustained virologic response rates > 95%. Analysis of those that received the label-recommended regimen found that the only 2 negative predictors associated with significantly lower response rates are obesity and genotype 1a disease. Even those with both factors achieved sustained virologic response rates of 95% at week 12.