RT Journal Article SR Electronic A1 Shuman, Jill T1 Treating Anticoagulant-Associated Bleeding JF MD Conference Express YR 2015 FD SAGE Publications VO 15 IS 21 SP 26 OP 27 DO 10.1177/1559897715599523 UL http://mdc.sagepub.com/content/15/21/26.abstract AB Agents that reverse the effect of vitamin K antagonists include plasma, vitamin K, and prothrombin complex concentrate. Hemostasis is most likely to be achieved by using a prothrombin complex concentrate. Guidelines for reversing the effect of direct-acting anticoagulants are based on guidelines that reflect the paucity of high-quality evidence.